Abstract
A total of 107 patients aged 60–89 years with proximal femur fractures were divided into a main group (n=43; antioxidant therapy guided by oxidative stress markers), a comparison group (n=41; antioxidants by a standard scheme) and a control group (n=23; no antioxidants). The total frequency of postoperative complications was 18.6%, 31.7% and 60.9%, respectively; delayed consolidation occurred in 7.0%, 12.2% and 21.7% and nonunion in 2.3%, 4.9% and 13.0% of patients. Mean consolidation time was 12.4±1.2, 14.1±1.4 and 16.3±1.6 weeks. Earlier union and fewer complications corresponded to a more pronounced decrease of malondialdehyde and a more complete restoration of superoxide dismutase activity. Antioxidant therapy guided by biochemical markers was more effective than a standard scheme.
References
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