POSTOPERATIVE COMPLICATIONS AND FRACTURE CONSOLIDATION TIME IN ELDERLY PATIENTS WITH PROXIMAL FEMUR FRACTURES DEPENDING ON THE ANTIOXIDANT THERAPY APPROACH
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Keywords

proximal femur fracture, elderly patients, antioxidant therapy, postoperative complications, fracture consolidation, nonunion, oxidative stress.

How to Cite

Nematov Dilshod, & Akramov Vokhid. (2026). POSTOPERATIVE COMPLICATIONS AND FRACTURE CONSOLIDATION TIME IN ELDERLY PATIENTS WITH PROXIMAL FEMUR FRACTURES DEPENDING ON THE ANTIOXIDANT THERAPY APPROACH. WORLD INTERNATIONAL CONFERENCE ON SCIENCE, TECHNOLOGY AND EDUCATION, 1(10), 15-18. https://doi.org/10.5281/zenodo.23243623

Abstract

A total of 107 patients aged 60–89 years with proximal femur fractures were divided into a main group (n=43; antioxidant therapy guided by oxidative stress markers), a comparison group (n=41; antioxidants by a standard scheme) and a control group (n=23; no antioxidants). The total frequency of postoperative complications was 18.6%, 31.7% and 60.9%, respectively; delayed consolidation occurred in 7.0%, 12.2% and 21.7% and nonunion in 2.3%, 4.9% and 13.0% of patients. Mean consolidation time was 12.4±1.2, 14.1±1.4 and 16.3±1.6 weeks. Earlier union and fewer complications corresponded to a more pronounced decrease of malondialdehyde and a more complete restoration of superoxide dismutase activity. Antioxidant therapy guided by biochemical markers was more effective than a standard scheme.

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References

1. Wu C., Gao B., Gui Y. Malondialdehyde on postoperative day 1 predicts postoperative cognitive dysfunction in elderly patients after hip fracture surgery // Bioscience Reports. – 2019. – Vol. 39, No. 6. – Art. BSR20190166. doi:10.1042/BSR20190166.

2. Kubo Y., Wruck C.J., Fragoulis A., Drescher W., Pape H.C., Lichte P., Fischer H., Tohidnezhad M., Hildebrand F., Pufe T., Jahr H. Role of Nrf2 in Fracture Healing: Clinical Aspects of Oxidative Stress // Calcified Tissue International. – 2019. – Vol. 105, No. 4. – P. 341–352. doi:10.1007/s00223-019-00576-3.