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Abstract
This study evaluated the role of biochemical parameters in predicting the course of preeclampsia in pregnant women. A total of 130 pregnant women participated, including patients with moderate and severe preeclampsia and a healthy control group. Significant changes in hemostatic, renal, and endothelial dysfunction biomarkers were identified. Increased levels of D-dimer, fibrinogen, NGAL, and cystatin C, along with decreased ADAMTS-13, were associated with disease severity. Comprehensive assessment of these biomarkers is important for early diagnosis, evaluation of severity, and prediction of thrombotic complications in preeclampsia.
References
1. World Health Organization. WHO recommendations for prevention and treatment of pre-eclampsia and eclampsia. Geneva: WHO; 2011.
2. American College of Obstetricians and Gynecologists. Gestational Hypertension and Preeclampsia. Practice Bulletin No. 222. Obstetrics & Gynecology. 2020;135(6):e237–e260.
3. Cunningham F.G., Leveno K.J., Bloom S.L., et al. Williams Obstetrics. 26th ed. New York: McGraw-Hill Education; 2022.
4. Sibai B.M. Etiology and management of preeclampsia. Obstetrics & Gynecology. 2003;102(1):181–192.
5. Podymow T., August P. Update on the use of antihypertensive drugs in pregnancy. Hypertension. 2008;51(4):960–969.