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Abstract
Premature rupture of membranes is one of the most urgent obstetric problems associated with increased perinatal morbidity and mortality. In recent years, special attention has been paid to the role of oxidative stress, inflammatory processes, and disorders of iron metabolism in the development of this pathology. This study investigated the pathogenetic significance of selenium and hepcidin in premature rupture of membranes. During the research, changes in selenium and hepcidin levels in pregnant women, as well as their relationship with inflammatory processes and oxidative stress, were analyzed. It was determined that selenium deficiency leads to a decrease in antioxidant defense, while alterations in hepcidin levels contribute to disturbances in iron metabolism and inflammatory reactions. These conditions weaken the structural stability of the fetal membranes and increase the risk of their premature rupture. The obtained results demonstrate the potential use of selenium and hepcidin as important biomarkers for the early diagnosis and prediction of premature rupture of membranes.
References
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