Abstract
Bronchial asthma (BA), being one of the most common chronic diseases of humans, is characterized by a high heterogeneity of clinical forms and variability of the course. The heterogeneity of BA manifests itself in varying degrees of bronchial obstruction severity, varying frequency of exacerbations, varying responses to bronchodilators and long-term control drugs, in particular, inhaled glucocorticosteroids. Modern management of BA requires a thorough analysis of the factors responsible for the progression of the disease and the development of exacerbations, as well as the development of targeted therapy for BA, taking into account the clinical and biological phenotypes of the disease. However, even now, in most patients with asthma, therapy can be conducted taking into account the phenotype of the disease, which is an important task of a specialist physician.
References
1. Rackemann F.M. // Am. J. Med. Sci. 1921. V. 12. P. 802.
2. Turner-Warwick M. // Br. J. Dis. Chest. 1977. V. 71. P. 73.
3. Федосеев Г.Б. Современное представление о причинах возникновения, особенностях течения и лечения бронхиальной астмы: Актовая речь. Л., 1982.
4. Wenzel S. // Lancet. 2006. V. 368. P. 804.
5. Johansson S.G. et al. // Allergy. 2001. V. 56. P. 813.
6. Simpson J.L. et al. // Respirology. 2006. V. 11. P. 54.
7. Nasser S.M. et al. // Am. J. Respir. Crit. Care Med. 1996. V. 153. P. 90.
8. Frew A.J. et al. // Am. J. Respir. Crit. Care Med. 1995. V. 151. P. 340.
9. Green R.H. et al. // Lancet. 2002. V. 360. P. 1715.
10. Jayaram L. et al. // Eur. Respir. J. 2006. V. 27. P. 483.
11. Simpson J.L. et al. // Am. J. Respir. Crit. Care Med. 2005. V. 172. P. 559.
12. Cundall M. et al. // J. Allergy Clin. Immunol. 2003. V. 112. P. 1064.
13. Green R.H. et al. // Thorax. 2002. V. 57. P. 875.
14. Berry M. et al. // Thorax. 2007. V. 62. P. 1043.
15. Cox G. // J. Immunol. 1995. V. 154. P. 4719.
16. Nguyen L.T. et al. // Respir. Med. 2005. V. 99. P. 200.
17. Petsky H.L. et al. // Thorax. 2012. V. 67. P. 199.
18. Green R.H., Pavord I. // Thorax. 2012. V. 67. P. 665.
19. Haldar P. et al. // Am. J. Respir. Crit. Care Med. 2008. V. 178. P. 218.
20. Moore W.C. et al. // Am. J. Respir. Crit. Care Med. 2010. V. 181. P. 315.
21. Wenzel S. // Clin. Exp. Allergy. 2012. V. 42. P. 650.
22. Anderson G.P. // Lancet. 2008. V. 372. P. 1107.
23. Lötvall J. et al. // J. Allergy Clin. Immunol. 2011. V. 127. P. 355.
24. Difficult-to-Treat Severe Asthma / Ed. by K.F. Chung et al. Eur. Respir. Mon. 2011. V. 51.
25. Walter S. et al. // Cochrane Database Syst. Rev. 2006. № 2. CD003559.
26. Rodrigo G.J. et al. // Chest. 2011. V. 139. P. 28.
27. Deeks E.D. et al. // Drugs. 2008. V. 68. P. 1741.
28. Tan R.A., Corren J. // Ther. Clin. Risk. Manag. 2008. V. 4. P. 1201.
29. Barnes P.J. // Eur. Respir. J. 2002. V. 19. P. 182.
30. Bai T.R. et al. // Eur. Respir. J. 2007. V. 30. P. 452.
31. Wu A.C. et al. // Chest. 2011. V. 140. P. 100.