Vol. 1 No. 5 (2026), Articles
Vol. 1 No. 5 (2026)

Clinical and Immunogenetic Features of Liver Fibrosis Development in Chronic Hepatitis of Various Etiologies: A Literature Review

Articles
Published 2026-05-31
Rasulov Boburjon
Assistant Lecturer, Department of Pharmacology, Clinical Pharmacology and Medical Biotechnology Andijan State Medical Institute
Ravzatov Jasurbek
PhD, Associate Professor, Department of Family Physician Training Andijan State Medical Institute
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Keywords

chronic hepatitis, liver fibrosis, immunogenetics, cytokines, genetic polymorphism, fibrogenesis, chronic inflammation, liver cirrhosis, molecular markers, personalized medicine.

How to Cite

Rasulov Boburjon, & Ravzatov Jasurbek. (2026). Clinical and Immunogenetic Features of Liver Fibrosis Development in Chronic Hepatitis of Various Etiologies: A Literature Review. INTERNATIONAL MULTIDISCIPLINARY SCIENCE CONFERENCE, 1(5), 329-333. https://doi.org/10.5281/zenodo.20532443
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Abstract

Chronic hepatitis of various etiologies remains one of the major causes of progressive liver damage worldwide. Persistent inflammatory processes in the liver can lead to fibrosis, cirrhosis, and ultimately liver failure. The development and progression of liver fibrosis are determined not only by the etiological factor but also by complex interactions among immune, genetic, and environmental mechanisms.

This literature review examines current scientific data on the clinical and immunogenetic characteristics of liver fibrosis development in patients with chronic hepatitis of different origins. Particular attention is given to the role of cytokines, immune response pathways, genetic polymorphisms, and molecular markers involved in fibrogenesis. The review also discusses the prognostic significance of immunogenetic factors and their potential application in early diagnosis, risk stratification, and personalized therapeutic approaches.

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References

1. World Health Organization. Global hepatitis report 2024: action for access in low- and middle-income countries. – Geneva: WHO, 2024. ISBN: 978-92-4-009167-2.

2. European Association for the Study of the Liver. EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver disease severity and prognosis – 2021 update // Journal of Hepatology. – 2021. – Vol. 75, №3. – P. 659–689. DOI: 10.1016/j.jhep.2021.05.025.

3. Paquissi F.C.F. Immunity and Fibrogenesis: The Role of Th17/IL-17 Axis in HBV and HCV-induced Chronic Hepatitis and Progression to Cirrhosis // Frontiers in Immunology. – 2017. – Vol. 8. – Article 1195. DOI: 10.3389/fimmu.2017.01195.

4. Gheshlaghi A., va hammualliflar. IL-17 Genetic Variations Increase the Risk of Cirrhotic/Hepatocellular Carcinoma in Patients with Hepatitis B Virus Infection // Iranian Journal of Immunology. – 2021. – Vol. 18, №2. – P. 130–140. DOI: 10.22034/iji.2021.88020.1852.

5. Xiao S., Zhou L., Li J., Pan X., Huang X., Liu Y., Wen S.W., Liu A. Gene polymorphisms of inflammatory factors in liver cirrhosis // Frontiers in Genetics. – 2023. – Vol. 14. – Article 1140427. DOI: 10.3389/fgene.2023.1140427.

6. Zhao Y.P., Wang H., Fang M., Ji Q., Yang Z.X., Gao C.F. Study of the association between polymorphisms of the COL1A1 gene and HBV-related liver cirrhosis in Chinese patients // Digestive Diseases and Sciences. – 2009. – Vol. 54, №2. – P. 369–376. DOI: 10.1007/s10620-008-0340-9.

7. Vujovic A., Isakovic A.M., Misirlic-Dencic S., Juloski J., Mirkovic M., Cirkovic A., Djelic M., Milošević I. IL-23/IL-17 Axis in Chronic Hepatitis C and Non-Alcoholic Steatohepatitis—New Insight into Immunohepatotoxicity of Different Chronic Liver Diseases // International Journal of Molecular Sciences. – 2023. – Vol. 24, №15. – Article 12483. DOI: 10.3390/ijms241512483.