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Abstract
Premature rupture of membranes is one of the most pressing problems in obstetrics, increasing the risk of preterm labor, neonatal infection, and perinatal mortality. In recent years, considerable attention has been paid to the study of biomarkers in order to expand the possibilities for early prediction of this pathology. This study analyzed the role of selenium and hepcidin biomarkers in the early prediction of premature rupture of membranes. During the research, changes in selenium and hepcidin levels in pregnant women and their relationship with oxidative stress, inflammatory processes, and iron metabolism were evaluated. It was determined that a decrease in selenium levels leads to weakened antioxidant defense and increased oxidative stress, while alterations in hepcidin levels are associated with inflammatory reactions and impaired iron homeostasis. These changes reduce the structural stability of the fetal membranes and increase the risk of their premature rupture. The obtained results demonstrated that selenium and hepcidin can be used as important biomarkers for the early diagnosis and prognostic assessment of premature rupture of membranes.
References
1. Najmutdinova D.K. Akusherlik va ginekologiyada perinatal asoratlarning klinik-prognostik jihatlari. — Toshkent: TTA, 2020.
2. Ayupova F.M. Akusherlik va ginekologiya. — Toshkent: Tibbiyot nashriyoti, 2019.
3. Karimov Z.D., Najmutdinova D.K. Homiladorlik asoratlari va perinatal xavf omillari. — Toshkent: TTA, 2021.
4. Cunningham F.G., Leveno K.J., Bloom S.L., Dashe J.S., Hoffman B.L., Casey B.M., Spong C.Y. Williams Obstetrics. — 26th ed. — New York: McGraw-Hill Education, 2022.
5. Gabbe S.G., Niebyl J.R., Simpson J.L. Obstetrics: Normal and Problem Pregnancies. — 8th ed. — Philadelphia: Elsevier, 2021.
6. Jiang H., et al. Premature rupture of membranes and pregnancy outcomes: current clinical aspects // Journal of Maternal-Fetal & Neonatal Medicine. — 2021.
7. Esteves J.S., et al. Preterm premature rupture of membranes and neonatal outcomes // Journal of Perinatal Medicine. — 2022.
8. Ildogan B.T., Ercan F.S., Purut C., Kaya Y.E., Karaaslan F., Onur. Hepcidin levels in pregnancies complicated by preterm premature rupture of membranes // Clinical and Experimental Obstetrics & Gynecology. — 2023.
9. Tara F., et al. The effect of selenium supplementation during pregnancy on preterm premature rupture of membranes // Journal of Obstetrics and Gynaecology. — 2010.