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Abstract
In recent years, the incidence, prevalence, mortality rates, and disability burden associated with motor neuron disease (MND) have significantly increased worldwide. Epidemiological analyses indicate that the global occurrence of the disease is closely associated with population aging, improvements in diagnostic capabilities, and the influence of environmental factors.
According to the 2021 Global Burden of Disease data, the global standardized incidence rate of MND averaged 1.68 per 100,000 population. The disease mainly occurs between the ages of 60 and 70 and is more frequently observed in men than in women.
References
1. Global Burden of Motor Neuron Disease Study 2021. Orphanet Journal of Rare Diseases, 2025.
2. Kai Liu et al. Global burden of motor neuron disease: aging dynamics and socioeconomic disparities. Journal of Neurology, 2025.
3. Park J.P. et al. The Global Burden of Motor Neuron Disease: GBD 2019 Analysis. Frontiers in Neurology, 2022.
4. Recent population-based epidemiological studies in Sweden and Czechia, 2024–2025.