Keywords
1,2,4-triazole; nucleoside analogues; antiviral agents; cytotoxicity; tumor cell lines; selectivity; medicinal chemistry
How to Cite
Tosheva , N., Sasmakov , S., & Azimova , S. (2026). Cytotoxic Activity of 1,2,4-Triazole Derivatives as Nucleoside Analogues with Antiviral Potential. INTERNATIONAL MULTIDISCIPLINARY SCIENCE CONFERENCE, 1(2), 172-173. https://doi.org/10.5281/zenodo.18666142
Abstract
The cytotoxic activity of 1,2,4-triazole–containing nucleoside analogues was evaluated in tumor and normal cell lines. The compounds showed no cytotoxic effects, in contrast to reference drugs, indicating high selectivity and supporting their potential as safe antiviral agents.
References
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2. Ilya V. Fateev., et al. Synthesis of Substituted 1,2,4-Triazole-3-Thione Nucleosides Using E. coli Purine Nucleoside Phosphorylase. Biomolecules. Volume 14, Issue 7; 2024 June.