Vol. 1 No. 2 (2026), Articles
Vol. 1 No. 2 (2026)

Clinical and Diagnostic Significance of Metabolic Dysfunction and Liver Fibrosis Stages in Patients with Non-Alcoholic Fatty Liver Disease (NAFLD)

Articles
Published 2026-02-13
  • Muhammadali Isroilov
  • Alisher Soliyev
Muhammadali Isroilov
Alisher Soliyev
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Keywords

NAFLD, Hepatology, Liver Fibrosis, Insulin Resistance, Transient Elastography, HOMA-IR.

How to Cite

Isroilov , M., & Soliyev , A. (2026). Clinical and Diagnostic Significance of Metabolic Dysfunction and Liver Fibrosis Stages in Patients with Non-Alcoholic Fatty Liver Disease (NAFLD). INTERNATIONAL MULTIDISCIPLINARY SCIENCE CONFERENCE, 1(2), 145-146. https://doi.org/10.5281/zenodo.18635080
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Abstract

Background: Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease worldwide.

 Methods: A prospective study of 84 patients was conducted to evaluate the link between metabolic markers and fibrosis. Liver stiffness was measured using transient elastography (FibroScan).

 Results: A significant correlation was found between HOMA-IR and fibrosis stage (r=0.58, p<0.05). Patients with BMI >30 kg/m² showed a 2.4-fold higher risk of advanced fibrosis (95% CI: 1.8–3.2).

Conclusion: Early metabolic intervention is crucial to prevent progression to cirrhosis. [112 words]

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References

1. EASL-EASD-EASO. Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease. J Hepatol. 2021.

2. Younossi ZM, et al. Global epidemiology of NAFLD. Hepatology. 2020.

3. Turdiev R.A., et al. Prevalence of metabolic syndrome in Uzbekistan. Journal of Internal Medicine. 2022.