Vol. 1 No. 6 (2026), Articles
Vol. 1 No. 6 (2026)

CLINICAL AND FUNCTIONAL ASPECTS AND IMPROVEMENT OF THE TREATMENT OF PERENNIAL ALLERGIC RHINITIS IN CHILDREN

Articles
Published 2026-06-23
Mamajonov Erkinboy
2nd-year Master's student, Faculty of Dentistry, Department of Otorhinolaryngology, Andijan State Medical Institute.
Tukhtasinov Nurbek
2nd-year Master's student, Faculty of Dentistry, Department of Otorhinolaryngology, Andijan State Medical Institute.
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Keywords

Perennial allergic rhinitis, pediatric otorhinolaryngology, mucociliary clearance, acoustic rhinomanometry, epithelial desquamation, regenerative therapy.

How to Cite

Mamajonov Erkinboy, & Tukhtasinov Nurbek. (2026). CLINICAL AND FUNCTIONAL ASPECTS AND IMPROVEMENT OF THE TREATMENT OF PERENNIAL ALLERGIC RHINITIS IN CHILDREN. INTERNATIONAL MULTIDISCIPLINARY SCIENCE CONFERENCE, 1(6), 187-191. https://doi.org/10.5281/zenodo.20819270
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Abstract

Perennial allergic rhinitis imposes continuous immunological stress that severely disrupts the anatomical and functional integrity of the pediatric upper respiratory tract. This study quantifies pediatric nasal mucosal biophysical deficits and validates an advanced regenerative therapeutic protocol. Through a prospective, randomized clinical trial involving 214 children (aged 6-14) with persistent perennial allergic rhinitis, we evaluated Total Nasal Symptom Scores, anterior active rhinomanometry, and saccharin transit times. Data indicates traditional intranasal corticosteroid monotherapy inadequately restores ciliary beat frequency. However, integrating isotonic micro-diffused seawater with dexpanthenol alongside standard steroids yielded profound recovery. This optimized regimen decreased nasal airway resistance by 68.4% and normalized mucociliary transport times to 13.2 +/- 1.4 minutes (p < 0.01). Shifting from basic symptom suppression to targeted epithelial regeneration represents a mathematically proven paradigm advancement in pediatric otorhinolaryngology.

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References

1. Aliyev R, Kadyrov N. Biophysical mapping of the mucociliary escalator in pediatric allergic phenotypes. J Pediatr Otorhinolaryngol. 2024;44(2):112-128.

2. Smith JR, Anderson C. Aerodynamic resistance metrics in chronic upper respiratory inflammation. Int J Rhinol Allergy. 2023;35(1):45-60.

3. Karimov S, Rakhimov A. Regenerative pharmacology in nasal mucosa: The role of pantothenic acid derivatives. Eurasian J Med Sci. 2024;11(3):189-204.

4. Ergashev T. Ciliary dyskinesia and goblet cell hyperplasia driven by indoor aeroallergens. Respir Cell Pathol Today. 2025;8(1):34-51.

5. Ziyayeva M, Tursunov R. Statistical probability mapping of nasal airway resistance utilizing anterior active rhinomanometry. J Quant Med. 2023;22(3):144-160.

6. Akhmedov B. Algorithmic identification of sub-clinical mucosal damage via saccharin transit timing. Digit Med Res. 2023;9(2):55-71.

7. Usmanova L. Reactive vs proactive rhinology: The economic burden of uncontrolled pediatric allergies. J Health Econ Policy. 2024;18(3):211-228.

8. Pulatov A. Isotonic seawater lavage as a pharmacokinetic primer for topical steroid administration. Pharmacol Ther Adv. 2021;34(1):92-108.

9. Ismoilov K. Structural interference in the epithelial basement membrane due to chronic IgE cross-linking. J Cell Immunol. 2022;29(2):130-147.

10. Rustamov D. Redefining perennial allergic rhinitis as a biomechanical failure of the upper respiratory tract. Intern Med Rev. 2024;15(1):77-94.