Vol. 1 No. 5 (2026), Articles
Vol. 1 No. 5 (2026)

THE SIGNIFICANCE OF SEX HORMONE METABOLISM AND GENETIC FACTORS IN NON-ALCOHOLIC FATTY LIVER DISEASE

Articles
Published 2026-05-31
Yunusova Dilfuza
Assistant Lecturer, Department of Normal Physiology Andijan State Medical Institute
Ravzatov Jasurbek
PhD, Associate Professor, Department of Family Physician Training Andijan State Medical Institute
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Keywords

non-alcoholic fatty liver disease (NAFLD), reproductive age, sex hormones, estrogen-androgen balance, insulin resistance, SHBG, CYP19A1, UGT2B15, UGT2B17.

How to Cite

Yunusova Dilfuza, & Ravzatov Jasurbek. (2026). THE SIGNIFICANCE OF SEX HORMONE METABOLISM AND GENETIC FACTORS IN NON-ALCOHOLIC FATTY LIVER DISEASE. INTERNATIONAL CONFERENCE ON MODERN RESEARCH AND SCIENTIFIC INNOVATION, 1(5), 267-270. https://doi.org/10.5281/zenodo.20532328
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Abstract

Non-alcoholic fatty liver disease (NAFLD) is a group of liver disorders that begins with excessive fat accumulation in hepatocytes and may subsequently progress to steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. In modern international clinical guidelines, this pathology is increasingly defined as metabolic dysfunction-associated steatotic liver disease (MASLD), characterized by hepatic steatosis together with the presence of cardiometabolic risk factors. This study examines the role of sex hormone metabolism and genetic factors in the development and progression of non-alcoholic fatty liver disease. Particular attention is given to the balance between estrogens and androgens, insulin resistance, sex hormone-binding globulin (SHBG), and genetic polymorphisms related to hormone metabolism. Understanding these mechanisms may contribute to improved diagnosis, risk assessment, and personalized therapeutic approaches for patients with NAFLD.

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