Abstract
In the scientific thesis, the authors analyze the clinical and laboratory indicators of 62 patients with infected pancreatic necrosis (IPC) against the background of diabetes mellitus (DM). The conducted studies showed that in the first phase of infected pancreatic necrosis in patients with diabetes mellitus, a pronounced increase in inflammatory markers and organ dysfunction was noted in the interval from 1 day to 3 days of the disease. In the second phase of IPN in patients with diabetes, a slow decrease in the early inflammatory response and a slowdown in the trend towards clinical improvement were observed, which was important for justifying a personalized approach.
References
1. Жураев Г.Г., Касымов А.Л., Мирзаев К.К.,Солиев М.Б. “Клиническая оценка отдаленных результатов комплексного лечения диабетической флегмоны нижних конечностей” Научные исследования и общественные проблемы volume 3, issue 1,2024 с11-14
2. Касымов А.Л., Жураев Г.Г., Нишонов М.Ф., Мирзаев К.К., Солиев М.Б. “Ближайшие и отдаленные результаты комплексного лечения гнойнонекротических поражений мягких тканей нижних конечностей у больных сахарным диабетом” Вестник ТМА №1, 2024 ISSN 2181-7812 С.103
3. Juraev G. G Kasymov A. L Sadikov R. A Soliev M. B Xojimetov D. Sh //Experimental substantitation of the use of laser irraditation and photodynamic therapy in diabetic femoral phlegmon// Central asian journal of medical and natural sciences volume: 04 issue: 04 | jul-aug 2023 issn: 2660-4159 С544-553
4. Juraev G.G., Kasymov A.L., Musashaikhov X.T., Xojimetov D.Sh., Soliev M.B. // Possibilities of laser and photodynamic therapy in the treatment of purulent-necrotic processes of the lower extremities in patients with diabetes mellitus// Article text-5764 Volume-26, september 2023 issn: 2749-3644 С1-9
5. Mahmadzoda F. I., Sadullozoda D. N., Murodov A. I. et al. Development of a method for laboratory diagnosis of early postoperative infectious complications // Semurg. - 2025. - No 26. - P. 28-35.
6. Musashaykhov Kh.T., Kosimov A.L., Salohiddinov K.Z., Musashaykhov U.Kh., Mirzayev K.K. Modern views on the problem of endogenous intoxication in acute pancreatitis and the choice of pathogenetically justified detoxification therapy (literature review) // Journal of modern medicine No1 (12), Volume 1, 2026. - P. 197-209.
7. Chelyapina T.P., Khripun A.I., Alimov A.N. et al. Endoscopic ultrasonography as an effective tool for predicting biliary pancreatitis complications // Evidence-based gastroenterology. - 2025. - Vol. 14, No. 3. - P. 22-28.
8. Masood M., Vedamurthy A., Krishnamoorthi R., et al. Interventional Management of Acute Pancreatitis and its Complications // J. Clin. Med. - 2025. - Vol. 14, No. 18. - P. 6683.
9. Mukai S., Sofuni A., Tsuchiya T., et al. Endoscopic Step-up Approach for Wall-off Necrosis After Acute Pancreatitis // DEN Open. - 2025. - Vol. 6, No. - P. e70188.
10. Yao Q., Duan Y., Jin C., et al. A nomogram for early prediction of infected pancreatic necrosis based on contrast-enhanced CT radiomics and inflammatory indicators // J. Inflamm. Res. - 2025. - Vol. 18. - P. 13651-13663.